Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of β-Arrestins

Protease-activated receptor-4 (PAR4) is a G protein-coupled receptor (GPCR) for thrombin and is proteolytically activated, similar to the prototypical PAR1. Due to the irreversible activation of PAR1, receptor trafficking is intimately linked to signal regulation. However, unlike PAR1, the mechanism...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Smith, Thomas H., Coronel, Luisa J., Li, Julia G., Dores, Michael R., Nieman, Marvin T., Trejo, JoAnn
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000090/
https://ncbi.nlm.nih.gov/pubmed/27402844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.729285
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