BubR1 Insufficiency Impairs Liver Regeneration in Aged Mice after Hepatectomy through Intercalated Disc Abnormality

A delay in liver regeneration after partial hepatectomy (PHx) leads to acute liver injury, and such delays are frequently observed in aged patients. BubR1 (budding uninhibited by benzimidazole-related 1) controls chromosome mitotic segregation through the spindle assembly checkpoint, and BubR1 down-...

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Udgivet i:Sci Rep
Main Authors: Ikawa-Yoshida, Ayae, Matsumoto, Takuya, Okano, Shinji, Aoyagi, Yukihiko, Matsubara, Yutaka, Furuyama, Tadashi, Nakatsu, Yoshimichi, Tsuzuki, Teruhisa, Onimaru, Mitsuho, Ohkusa, Tomoko, Nomura, Masatoshi, Maehara, Yoshihiko
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4999951/
https://ncbi.nlm.nih.gov/pubmed/27561386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32399
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