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Pubertal Expression of α4βδ GABA(A) Receptors Reduces Seizure-Like Discharges in CA1 Hippocampus

More than half of children with epilepsy outgrow their seizures, yet the underlying mechanism is unknown. GABAergic inhibition increases at puberty in female mice due to expression of extrasynaptic α4βδ GABA(A) receptors (GABARs). Therefore, we tested the role of these receptors in regulating seizur...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Yang, Lie, Shen, Hui, Merlin, Lisa R., Smith, Sheryl S.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4999950/
https://ncbi.nlm.nih.gov/pubmed/27561815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31928
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