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Inflammation-driven carcinogenesis is mediated through STING

Chronic stimulation of innate immune pathways by microbial agents or damaged tissue is known to promote inflammation-driven tumorigenesis by mechanisms that are not well understood. Here we demonstrate that mutagenic 7,12-dimethylbenz(a)anthracene (DMBA), cisplatin and etoposide induce nuclear DNA l...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ahn, Jeonghyun, Xia, Tianli, Konno, Hiroyasu, Konno, Keiko, Ruiz, Phillip, Barber, Glen N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4998973/
https://ncbi.nlm.nih.gov/pubmed/25300616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6166
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