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HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis
During the early stages of infection, the HIV-1 capsid protects viral components from cytosolic sensors, such as cGAS, and nucleases, such as TREX, while allowing access to nucleotides for efficient reverse transcription1. Here we show that each capsid hexamer has a size-selective pore bounded by a...
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| Pubblicato in: | Nature |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4998957/ https://ncbi.nlm.nih.gov/pubmed/27509857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature19098 |
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