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Pharmacological Characterization of the Spectrum of Antiviral Activity and Genetic Barrier to Drug Resistance of M2-S31N Channel Blockers
Adamantanes (amantadine and rimantadine) are one of the two classes of Food and Drug Administration–approved antiviral drugs used for the prevention and treatment of influenza A virus infections. They inhibit viral replication by blocking the wild-type (WT) M2 proton channel, thus preventing viral u...
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| Published in: | Mol Pharmacol |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
The American Society for Pharmacology and Experimental Therapeutics
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4998667/ https://ncbi.nlm.nih.gov/pubmed/27385729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.105346 |
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