Role of Inflammatory and Oxidative Stress, Cytochrome P450 2E1, and Bile Acid Disturbance in Rat Liver Injury Induced by Isoniazid and Lipopolysaccharide Cotreatment

Isoniazid (INH) remains the core drug in tuberculosis management, but serious hepatotoxicity and potentially fatal liver injury continue to accompany INH consumption. Among numerous theories that have been established to explain INH-induced liver injury, an inflammatory stress theory has recently be...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Hassan, Hozeifa Mohamed, Guo, Hongli, Yousef, Bashir Alsiddig, Guerram, Mounia, Hamdi, Aida Mejda, Zhang, Luyong, Jiang, Zhenzhou
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4997853/
https://ncbi.nlm.nih.gov/pubmed/27324775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00854-16
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