MTAP deletion confers enhanced dependency on the arginine methyltransferase PRMT5 in human cancer cells

The discovery of cancer dependencies has the potential to inform therapeutic strategies and to identify putative drug targets. Integrating data from comprehensive genomic profiling of cancer cell lines and from functional characterization of cancer cell dependencies, we discovered that loss of the e...

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Publicado en:Science
Main Authors: Kryukov, Gregory V, Wilson, Frederick H, Ruth, Jason R, Paulk, Joshiawa, Tsherniak, Aviad, Marlow, Sara E, Vazquez, Francisca, Weir, Barbara A, Fitzgerald, Mark E, Tanaka, Minoru, Bielski, Craig M, Scott, Justin M, Dennis, Courtney, Cowley, Glenn S, Boehm, Jesse S, Root, David E, Golub, Todd R, Clish, Clary B, Bradner, James E, Hahn, William C, Garraway, Levi A
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4997612/
https://ncbi.nlm.nih.gov/pubmed/26912360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad5214
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