Insights into significance of combined inhibition of MEK and m-TOR signalling output in KRAS mutant non-small-cell lung cancer

BACKGROUND: We aimed to understand the dependence of MEK and m-TOR inhibition in EGFR(WT)/ALK(non-rearranged) NSCLC cell lines. METHODS: In a panel of KRAS(M) and KRAS(WT) NSCLC cell lines, we determined growth inhibition (GI) following maximal reduction in p-ERK and p-S6RP caused by trametinib (MEK...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Cancer
Hauptverfasser: Broutin, Sophie, Stewart, Adam, Thavasu, Parames, Paci, Angelo, Bidart, Jean-Michel, Banerji, Udai
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Translational Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4997545/
https://ncbi.nlm.nih.gov/pubmed/27441499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.220
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