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The emergence of superstructural order in insulin amyloid fibrils upon multiple rounds of self-seeding

Typically, elongation of an amyloid fibril entails passing conformational details of the mother seed to daughter generations of fibrils with high fidelity. There are, however, several factors that can potentially prevent such transgenerational structural imprinting from perpetuating, for example het...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Surmacz-Chwedoruk, Weronika, Babenko, Viktoria, Dec, Robert, Szymczak, Piotr, Dzwolak, Wojciech
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4997315/
https://ncbi.nlm.nih.gov/pubmed/27558445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32022
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