Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease‐activated receptor‐2

BACKGROUND AND PURPOSE: Diverse proteases cleave protease‐activated receptor‐2 (PAR2) on primary sensory neurons and epithelial cells to evoke pain and inflammation. Trypsin and tryptase activate PAR2 by a canonical mechanism that entails cleavage within the extracellular N‐terminus revealing a teth...

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Bibliographic Details
Published in:Br J Pharmacol
Main Authors: Lieu, T, Savage, E, Zhao, P, Edgington‐Mitchell, L, Barlow, N, Bron, R, Poole, D P, McLean, P, Lohman, R‐J, Fairlie, D P, Bunnett, N W
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
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Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995288/
https://ncbi.nlm.nih.gov/pubmed/27423137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13554
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