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High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival
Chronic infections induce T cells showing impaired cytokine secretion and up-regulated expression of inhibitory receptors such as PD-1. What determines the acquisition of this chronic phenotype and how it impacts T cell function remain vaguely understood. Using newly generated recombinant antigen va...
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| Veröffentlicht in: | J Exp Med |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4995073/ https://ncbi.nlm.nih.gov/pubmed/27455951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150598 |
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