Metformin Restrains Pancreatic Duodenal Homeobox-1 (PDX-1) Function by Inhibiting ERK Signaling in Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is one of the most potent and perilous diseases known, with a median survival rate of 3-5 months due to the combination of only advanced stage diagnosis and ineffective therapeutic options. Metformin (1,1-Dimethylbiguanide hydrochloride), the leading drug used...

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Publicado en:Curr Mol Med
Main Authors: Zhou, G., Yu, J., Wang, A., Liu, S.-H., Sinnett-Smith, J., Wu, J., Sanchez, R., Nemunaitis, J., Ricordi, C., Rozengurt, E., Brunicardi, F.C.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4994969/
https://ncbi.nlm.nih.gov/pubmed/26695692
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