Large-Scale Recombinant Expression and Purification of Human Tyrosinase Suitable for Structural Studies

Human tyrosinase (TYR) is a glycoprotein that initiates the first two reactions in the melanin biosynthesis pathway. Mutations in its encoding gene cause Oculocutaneous Albinism type I (OCA1), the most severe form of albinism, which is a group of autosomal recessive disorders characterized by reduce...

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Bibliographic Details
Published in:PLoS One
Main Authors: Lai, Xuelei, Soler-Lopez, Montserrat, Wichers, Harry J., Dijkstra, Bauke W.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4994950/
https://ncbi.nlm.nih.gov/pubmed/27551823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161697
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