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An expression vector tailored for large-scale, high-throughput purification of recombinant proteins

Production of milligram quantities of numerous proteins for structural and functional studies requires an efficient purification pipeline. We found that the dual tag, his(6)-tag–maltose-binding protein (MBP), intended to facilitate purification and enhance proteins’ solubility, disrupted such a pipe...

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Detalhes bibliográficos
Main Authors: Donnelly, Mark I., Zhou, Min, Millard, Cynthia Sanville, Clancy, Shonda, Stols, Lucy, Eschenfeldt, William H., Collart, Frank R., Joachimiak, Andrzej
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2792030/
https://ncbi.nlm.nih.gov/pubmed/16497515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pep.2005.12.011
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