Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering

Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) each give rise to a vast array of complex bioactive molecules with further complexity added by the existence of natural PKS-NRPS fusions. Rational genetic engineering for the production of natural product derivatives is desirab...

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發表在:PLoS One
Main Authors: Nielsen, Maria Lund, Isbrandt, Thomas, Petersen, Lene Maj, Mortensen, Uffe Hasbro, Andersen, Mikael Rørdam, Hoof, Jakob Blæsbjerg, Larsen, Thomas Ostenfeld
格式: Artigo
語言:Inglês
出版: Public Library of Science 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4994942/
https://ncbi.nlm.nih.gov/pubmed/27551732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161199
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