Identification of Multiple QTLs Linked to Neuropathology in the Engrailed-1 Heterozygous Mouse Model of Parkinson’s Disease

Motor symptoms in Parkinson’s disease are attributed to degeneration of midbrain dopaminergic neurons (DNs). Heterozygosity for Engrailed-1 (En1), one of the key factors for programming and maintenance of DNs, results in a parkinsonian phenotype featuring progressive degeneration of DNs in substanti...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Kurowska, Zuzanna, Jewett, Michael, Brattås, Per Ludvik, Jimenez-Ferrer, Itzia, Kenéz, Xuyian, Björklund, Tomas, Nordström, Ulrika, Brundin, Patrik, Swanberg, Maria
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4994027/
https://ncbi.nlm.nih.gov/pubmed/27550741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31701
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