Indomethacin induces increase in gastric epithelial tight junction permeability via redistribution of occludin and activation of p38 MAPK in MKN-28 Cells

Tight Junctions (TJ) create a paracellular barrier that is compromised when nonsteriodal anti-inflammatory drugs (NSAIDs) injure the gastric epithelium, leading to increased permeability. However, the mechanism of NSAID-induced gastric injury is unclear. Here, we examined the effect of indomethacin...

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Bibliographische Detailangaben
Veröffentlicht in:Tissue Barriers
Hauptverfasser: Thakre-Nighot, Meghali, Blikslager, Anthony T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993575/
https://ncbi.nlm.nih.gov/pubmed/27583191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21688370.2016.1187325
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