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The importance of L1 ORF2p cryptic sequence to ORF2p fragment-mediated cytotoxicity
The Long Interspersed Element 1 (LINE1 or L1) ORF2 protein (ORF2p) can cause DNA damage through the activity of its endonuclease domain (EN). The DNA double-strand breaks (DSB) introduced by the ORF2p EN have the potential to be mutagenic. Previously, our lab has shown that ORF2p fragments containin...
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| Publicado no: | Mob Genet Elements |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4993571/ https://ncbi.nlm.nih.gov/pubmed/27583184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2159256X.2016.1198300 |
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