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The importance of L1 ORF2p cryptic sequence to ORF2p fragment-mediated cytotoxicity

The Long Interspersed Element 1 (LINE1 or L1) ORF2 protein (ORF2p) can cause DNA damage through the activity of its endonuclease domain (EN). The DNA double-strand breaks (DSB) introduced by the ORF2p EN have the potential to be mutagenic. Previously, our lab has shown that ORF2p fragments containin...

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Publicat a:Mob Genet Elements
Autors principals: Christian, Claiborne M., Kines, Kristine J., Belancio, Victoria P.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993571/
https://ncbi.nlm.nih.gov/pubmed/27583184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2159256X.2016.1198300
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