The endonuclease domain of the LINE-1 ORF2 protein can tolerate multiple mutations

BACKGROUND: Approximately 17 % of the human genome is comprised of the Long INterspersed Element-1 (LINE-1 or L1) retrotransposon, the only currently active autonomous family of retroelements. Though L1 elements have helped to shape mammalian genome evolution over millions of years, L1 activity can...

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Bibliographic Details
Published in:Mob DNA
Main Authors: Kines, Kristine J., Sokolowski, Mark, deHaro, Dawn L., Christian, Claiborne M., Baddoo, Melody, Smither, Madison E., Belancio, Victoria P.
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4837594/
https://ncbi.nlm.nih.gov/pubmed/27099633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13100-016-0064-x
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