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Excess free histone H3 localizes to centrosomes for proteasome-mediated degradation during mitosis in metazoans

The cell tightly controls histone protein levels in order to achieve proper packaging of the genome into chromatin, while avoiding the deleterious consequences of excess free histones. Our accompanying study has shown that a histone modification that loosens the intrinsic structure of the nucleosome...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Wike, Candice L., Graves, Hillary K., Wason, Arpit, Hawkins, Reva, Gopalakrishnan, Jay, Schumacher, Jill, Tyler, Jessica K.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993543/
https://ncbi.nlm.nih.gov/pubmed/27248858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1192728
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