Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis

Phosphorylation of histone H3 threonine 118 (H3 T118ph) weakens histone DNA-contacts, disrupting the nucleosome structure. We show that Aurora-A mediated H3 T118ph occurs at pericentromeres and chromosome arms during prophase and is lost upon chromosome alignment. Expression of H3 T118E or H3 T118I...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Wike, Candice L, Graves, Hillary K, Hawkins, Reva, Gibson, Matthew D, Ferdinand, Michelle B, Zhang, Tao, Chen, Zhihong, Hudson, Damien F, Ottesen, Jennifer J, Poirier, Michael G, Schumacher, Jill, Tyler, Jessica K
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Genes and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4798946/
https://ncbi.nlm.nih.gov/pubmed/26878753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11402
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