BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein

BRCA2 is responsible for familial breast and ovarian cancer and has been linked to DNA repair and centrosome duplication. Here we analyzed the mechanism by which the centrosomal localization signal (CLS) of BRCA2 interacts with cytoplasmic dynein 1 to localize BRCA2 to the centrosome. In vitro pull-...

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Bibliografiske detaljer
Udgivet i:Cell Cycle
Main Authors: Malik, Sadiya, Saito, Hiroko, Takaoka, Miho, Miki, Yoshio, Nakanishi, Akira
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
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Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993541/
https://ncbi.nlm.nih.gov/pubmed/27433848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1195531
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