Clonal hematopoiesis as determined by the HUMARA assay is a marker for acquired mutations in epigenetic regulators in older women

Recent large cohort studies revealed that healthy older individuals harbor somatic mutations that increase their risk for hematologic malignancy and all-cause cardiovascular deaths. The majority of these mutations are in chromatin and epigenetic regulatory genes (CERGs). CERGs play a key role in reg...

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Gepubliceerd in:Exp Hematol
Hoofdauteurs: Wiedmeier, J Erin, Kato, Catherine, Zhang, Zhenzhen, Lee, Hyunjung, Dunlap, Jennifer, Nutt, Eric, Rattray, Rogan, McKay, Sarah, Eide, Christopher, Press, Richard, Mori, Motomi, Druker, Brian, Dao, Kim-Hien
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993458/
https://ncbi.nlm.nih.gov/pubmed/27235757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2016.05.009
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