Evasion of cell senescence in SHH medulloblastoma

The mechanisms leading to brain tumor formation are poorly understood. Using Ptch1(+/−) mice as a medulloblastoma model, sequential mutations were found to shape tumor evolution. Initially, medulloblastoma preneoplastic lesions display loss of heterozygosity of the Ptch1 wild-type allele, an event a...

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Udgivet i:Cell Cycle
Main Authors: Tamayo-Orrego, Lukas, Swikert, Shannon M., Charron, Frédéric
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993422/
https://ncbi.nlm.nih.gov/pubmed/27229128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1189044
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