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Evasion of cell senescence in SHH medulloblastoma
The mechanisms leading to brain tumor formation are poorly understood. Using Ptch1(+/−) mice as a medulloblastoma model, sequential mutations were found to shape tumor evolution. Initially, medulloblastoma preneoplastic lesions display loss of heterozygosity of the Ptch1 wild-type allele, an event a...
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| 出版年: | Cell Cycle |
|---|---|
| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Taylor & Francis
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4993422/ https://ncbi.nlm.nih.gov/pubmed/27229128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1189044 |
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