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Single-cell, Time-resolved Antimicrobial Effects of a Highly Cationic, Random Nylon-3 Copolymer on Live E. coli

Synthetic random copolymers based on the nylon-3 (β-peptide) backbone show promise as inexpensive antimicrobial agents resistant to proteolysis. We present a time-resolved observational study of the attack of a particular copolymer MM(63):CHx(37) on single, live E. coli cells. The composition and ch...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Choi, Heejun, Chakraborty, Saswata, Liu, Runhui, Gellman, Samuel H., Weisshaar, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992573/
https://ncbi.nlm.nih.gov/pubmed/26493221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00547
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