The toxin biliatresone causes mouse extrahepatic cholangiocyte damage and fibrosis through decreased glutathione and SOX17

Biliary atresia, the most common indication for pediatric liver transplantation, is a fibrotic disease of unknown etiology affecting the extrahepatic bile ducts of newborns. The recently described toxin biliatresone causes lumen obstruction in mouse cholangiocyte spheroids and represents a new model...

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Библиографические подробности
Опубликовано в: :Hepatology
Главные авторы: Waisbourd‐Zinman, Orith, Koh, Hong, Tsai, Shannon, Lavrut, Pierre‐Marie, Dang, Christine, Zhao, Xiao, Pack, Michael, Cave, Jeff, Hawes, Mark, Koo, Kyung A., Porter, John R., Wells, Rebecca G.
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2016
Предметы:
Autoimmune, Cholestatic and Biliary Disease
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992464/
https://ncbi.nlm.nih.gov/pubmed/27081925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28599
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