The toxin biliatresone causes mouse extrahepatic cholangiocyte damage and fibrosis through decreased glutathione and SOX17

Biliary atresia, the most common indication for pediatric liver transplantation, is a fibrotic disease of unknown etiology affecting the extrahepatic bile ducts of newborns. The recently described toxin biliatresone causes lumen obstruction in mouse cholangiocyte spheroids and represents a new model...

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Publicado en:Hepatology
Autores principales: Waisbourd‐Zinman, Orith, Koh, Hong, Tsai, Shannon, Lavrut, Pierre‐Marie, Dang, Christine, Zhao, Xiao, Pack, Michael, Cave, Jeff, Hawes, Mark, Koo, Kyung A., Porter, John R., Wells, Rebecca G.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
Materias:
Autoimmune, Cholestatic and Biliary Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992464/
https://ncbi.nlm.nih.gov/pubmed/27081925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28599
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