Glutathione Antioxidant Pathway Activity and Reserve Determine Toxicity and Specificity of the Biliary Toxin Biliatresone in Zebrafish

Biliatresone is an electrophilic isoflavone isolated from Dysphania species plants that has been causatively linked to naturally occurring outbreaks of a biliary atresia (BA)-like disease in livestock. Biliatresone has selective toxicity for extrahepatic cholangiocytes (EHC) in zebrafish larvae. To...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Zhao, Xiao, Lorent, Kristin, Wilkins, Benjamin, Marchione, Dylan M., Gillespie, Kevin, Waisbourd-Zinman, Orith, So, Juhoon, Koo, Kyung Ah, Shin, Donghun, Porter, John R., Wells, Rebecca G., Blair, Ian, Pack, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5251204/
https://ncbi.nlm.nih.gov/pubmed/27102575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28603
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