Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1

The activating NK-cell receptor KIR3DS1 has been implicated in the outcome of various human diseases, including delayed HIV-1 disease progression, yet a ligand that accounts for its biological effects remained unknown. We screened 100 HLA-I proteins and found that KIR3DS1 binds HLA-F, which was vali...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Immunol
Hlavní autoři: Garcia-Beltran, Wilfredo F., Hölzemer, Angelique, Martrus, Gloria, Chung, Amy W., Pacheco, Yovana, Simoneau, Camille R., Rucevic, Marijana, Lamothe-Molina, Pedro A., Pertel, Thomas, Kim, Tae-Eun, Dugan, Haley, Alter, Galit, Dechanet-Merville, Julie, Jost, Stephanie, Carrington, Mary, Altfeld, Marcus
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992421/
https://ncbi.nlm.nih.gov/pubmed/27455421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3513
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky