Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival

Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some cases, worsened disease outcome. Here we examine colon cancer patients and show...

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Vydáno v:Oncotarget
Hlavní autoři: Dowling, Catríona M., Phelan, James, Callender, Julia A., Cathcart, Mary Clare, Mehigan, Brian, McCormick, Paul, Dalton, Tara, Coffey, John C., Newton, Alexandra C., O'sullivan, Jacintha, Kiely, Patrick A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991501/
https://ncbi.nlm.nih.gov/pubmed/26989024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8062
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