Reactivation of epigenetically silenced miR-124 reverses the epithelial-to-mesenchymal transition and inhibits invasion in endometrial cancer cells via the direct repression of IQGAP1 expression

Overexpression of IQGAP1 and microRNA (miRNA) dysregulation are frequent in human tumors, but little is known about the role of IQGAP1 and its relationship to miRNA in endometrial carcinogenesis. We demonstrate that IQGAP1 activates the epithelial–mesenchymal transition (EMT) program and that miR-12...

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Publicado en:Oncotarget
Autores principales: Dong, Peixin, Ihira, Kei, Xiong, Ying, Watari, Hidemichi, Hanley, Sharon J.B., Yamada, Takahiro, Hosaka, Masayoshi, Kudo, Masataka, Yue, Junming, Sakuragi, Noriaki
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991452/
https://ncbi.nlm.nih.gov/pubmed/26934121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7754
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