Reactivating p53 functions by suppressing its novel inhibitor iASPP: a potential therapeutic opportunity in p53 wild-type tumors

Although mutational inactivation of p53 is found in 50% of all human tumors, a subset of tumors display defective p53 function, but retain wild-type (WT) p53. Here, direct and indirect mechanisms leading to the loss of WT p53 activities are discussed. We summarize the oncogenic roles of iASPP, an in...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Dong, Peixin, Ihira, Kei, Hamada, Junichi, Watari, Hidemichi, Yamada, Takahiro, Hosaka, Masayoshi, Hanley, Sharon J.B., Kudo, Masataka, Sakuragi, Noriaki
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2015
Pynciau:
Review
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652980/
https://ncbi.nlm.nih.gov/pubmed/26343523
Tagiau: Ychwanegu Tag
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