Fibroblast-induced switching to the mesenchymal-like phenotype and PI3K/mTOR signaling protects melanoma cells from BRAF inhibitors

The knowledge on how tumor-associated stroma influences efficacy of anti-cancer therapy just started to emerge. Here we show that lung fibroblasts reduce melanoma sensitivity to the BRAF inhibitor (BRAFi) vemurafenib only if the two cell types are in close proximity. In the presence of fibroblasts,...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Seip, Kotryna, Fleten, Karianne G., Barkovskaya, Anna, Nygaard, Vigdis, Haugen, Mads H., Engesæter, Birgit Ø., Mælandsmo, Gunhild M., Prasmickaite, Lina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991434/
https://ncbi.nlm.nih.gov/pubmed/26918352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7671
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