Concomitant BRAF and PI3K/mTOR Blockade is Required for Effective Treatment of BRAF(V600E) Colorectal Cancer

PURPOSE: BRAF(V600E) mutations are associated with poor clinical prognosis in colorectal cancer (CRC). Whereas selective BRAF inhibitors are effective for treatment of melanoma, comparable efforts in CRC have been disappointing. Here, we investigated potential mechanisms underlying this resistance t...

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Autori principali: Coffee, Erin M., Faber, Anthony C., Roper, Jatin, Sinnamon, Mark J., Goel, Gautam, Keung, Lily, Wang, Wei Vivian, Vecchione, Loredana, de Vriendt, Veerle, Weinstein, Barbara J., Bronson, Roderick T., Tejpar, Sabine, Xavier, Ramnik J., Engelman, Jeffrey A., Martin, Eric S., Hung, Kenneth E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815598/
https://ncbi.nlm.nih.gov/pubmed/23549875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2556
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