ZSTK474, a specific class I phosphatidylinositol 3-kinase inhibitor, induces G1 arrest and autophagy in human breast cancer MCF-7 cells

Multifaceted activities of class I phosphatidylinositol 3-kinase (PI3K) inhibitor ZSTK474 were investigated on human breast cancer cell MCF-7. ZSTK474 inhibited proliferation of MCF-7 cells potently. Flow cytometric analysis indicated that ZSTK474 induced cell cycle arrest at G1 phase, but no obviou...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Wang, Yaochen, Liu, Jing, Qiu, Yuling, Jin, Meihua, Chen, Xi, Fan, Guanwei, Wang, Ran, Kong, Dexin
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991426/
https://ncbi.nlm.nih.gov/pubmed/26918351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7658
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