5-Fluorouracil targets thymidylate synthase in the selective suppression of T(H)17 cell differentiation

While it is well established that treatment of cancer patients with 5-Fluorouracil (5-FU) can result in immune suppression, the exact function of 5-FU in the modulation of immune cells has not been fully established. We found that low dose 5-FU selectively suppresses T(H)17 and T(H)1 cell differenti...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Wang, Juan, Peng, Liang, Zhang, Ruihua, Zheng, Zihan, Chen, Chun, Cheung, Ka Lung, Cui, Miao, Bian, Guanglin, Xu, Feihong, Chiang, David, Hu, Yuan, Chen, Ye, Lu, Geming, Yang, Jianjun, Zhang, Hui, Yang, Jianfei, Zhu, Hongfa, Chen, Shu-hsia, Liu, Kebin, Zhou, Ming-Ming, Sikora, Andrew G., Li, Liwu, Jiang, Bo, Xiong, Huabao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
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Research Paper: Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991385/
https://ncbi.nlm.nih.gov/pubmed/27027355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8344
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