Reprogramming macrophage orientation by microRNA 146b targeting transcription factor IRF5

The regulation of macrophage orientation pathological conditions is important but still incompletely understood. Here, we show that IL-10 and Rag1 double knockout mice spontaneously develop colitis with dominant M1 macrophage phenotype, suggesting that IL-10 regulates macrophage orientation in infla...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:EBioMedicine
Main Authors: Peng, Liang, Zhang, Hui, Hao, Yuanyuan, Xu, Feihong, Yang, Jianjun, Zhang, Ruihua, Lu, Geming, Zheng, Zihan, Cui, Miao, Qi, Chen-Feng, Chen, Chun, Wang, Juan, Hu, Yuan, Wang, Di, Pierce, Susan, Li, Liwu, Xiong, Huabao
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2016
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161420/
https://ncbi.nlm.nih.gov/pubmed/27825654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.10.041
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