Phospho-BAD BH3 Mimicry Protects β Cells and Restores Functional β Cell Mass in Diabetes

Strategies that simultaneously enhance the survival and glucose responsiveness of insulin-producing β cells will greatly augment β cell replacement therapies in type 1 diabetes (T1D). We show that genetic and pharmacologic mimetics of the phosphorylated BCL-2 homology 3 (BH3) domain of BAD impart β...

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Pubblicato in:Cell Rep
Autori principali: Ljubicic, Sanda, Polak, Klaudia, Fu, Accalia, Wiwczar, Jessica, Szlyk, Benjamin, Chang, Yigang, Alvarez-Perez, Juan C., Bird, Gregory H., Walensky, Loren D., Garcia-Ocaña, Adolfo, Danial, Nika N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991214/
https://ncbi.nlm.nih.gov/pubmed/25640178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.12.056
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