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The inhibition of EZH2 ameliorates osteoarthritis development through the Wnt/β-catenin pathway

The purpose of our study was to elucidate the role of the histone methyltransferase enhancer of zeste homologue 2 (EZH2) in the pathophysiology of osteoarthritis (OA) and to develop a strategy to modulate EZH2 activity for OA treatment. The expression of EZH2 in normal and OA human cartilage was com...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Chen, Linwei, Wu, Yaosen, Wu, Yan, Wang, Ye, Sun, Liaojun, Li, Fangcai
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990905/
https://ncbi.nlm.nih.gov/pubmed/27539752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29176
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