Creation of an engineered APC system to explore and optimize the presentation of immunodominant peptides of major allergens

We have generated engineered APC to present immunodominant peptides derived from the major aero-allergens of birch and mugwort pollen, Bet v 1(142–153) and Art v 1(25–36), respectively. Jurkat-based T cell reporter lines expressing the cognate allergen-specific T cell receptors were used to read out...

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Foilsithe in:Sci Rep
Main Authors: Rosskopf, Sandra, Jutz, Sabrina, Neunkirchner, Alina, Candia, Martín R., Jahn-Schmid, Beatrice, Bohle, Barbara, Pickl, Winfried F., Steinberger, Peter
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990899/
https://ncbi.nlm.nih.gov/pubmed/27539532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31580
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