Creation of an engineered APC system to explore and optimize the presentation of immunodominant peptides of major allergens

We have generated engineered APC to present immunodominant peptides derived from the major aero-allergens of birch and mugwort pollen, Bet v 1(142–153) and Art v 1(25–36), respectively. Jurkat-based T cell reporter lines expressing the cognate allergen-specific T cell receptors were used to read out...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Rosskopf, Sandra, Jutz, Sabrina, Neunkirchner, Alina, Candia, Martín R., Jahn-Schmid, Beatrice, Bohle, Barbara, Pickl, Winfried F., Steinberger, Peter
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990899/
https://ncbi.nlm.nih.gov/pubmed/27539532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31580
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