Reversal of multidrug resistance of hepatocellular carcinoma cells by metformin through inhibiting NF-κB gene transcription

AIM: To interfere with the activation of nuclear factor-κB (NF-κB) with metformin and explore its effect in reversing multidrug resistance (MDR) of hepatocellular carcinoma (HCC) cells. METHODS: Expression of P-glycoprotein (P-gp) and NF-κB in human HepG2 or HepG2/adriamycin (ADM) cells treated with...

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Publicado en:World J Hepatol
Autores principales: Wu, Wei, Yang, Jun-Ling, Wang, Yi-Lang, Wang, Han, Yao, Min, Wang, Li, Gu, Juan-Juan, Cai, Yin, Shi, Yun, Yao, Deng-Fu
Formato: Artigo
Lenguaje:Inglês
Publicado: Baishideng Publishing Group Inc 2016
Materias:
Basic Study
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990762/
https://ncbi.nlm.nih.gov/pubmed/27621764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4254/wjh.v8.i23.985
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