Improving Cancer Chemoradiotherapy Treatment by Dual Controlled Release of Wortmannin and Docetaxel in Polymeric Nanoparticles

Combining molecularly targeted agents and chemotherapeutics is an emerging strategy in cancer treatment. We engineered sub-50 nm diameter diblock copolymer nanoparticles (NPs) that can sequentially release wortmannin (Wtmn, a cell signaling inhibitor) and docetaxel (Dtxl, genotoxic anticancer agent)...

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發表在:ACS Nano
Main Authors: Au, Kin Man, Min, Yuanzeng, Tian, Xi, Zhang, Longzhen, Perello, Virginia, Caster, Joseph M., Wang, Andrew Z.
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990743/
https://ncbi.nlm.nih.gov/pubmed/26267360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.5b02913
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