Effect of particle size on the biodistribution, toxicity, and efficacy of drug-loaded polymeric nanoparticles in chemoradiotherapy

Nanoparticle (NP) therapeutics can improve the therapeutic index of chemoradiotherapy (CRT). However, the effect of NP physical properties, such particle size, on CRT is unknown. To address this, we examined the effects of NP size on biodistribution, efficacy and toxicity in CRT. PEG-PLGA NPs (50, 1...

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Bibliografiske detaljer
Udgivet i:Nanomedicine
Main Authors: Caster, Joseph M., Yu, Stephanie K., Patel, Artish N., Newman, Nicole J., Lee, Zachary J., Warner, Samuel B., Wagner, Kyle T., Roche, Kyle C., Tian, Xi, Min, Yuanzeng, Wang, Andrew Z.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5483200/
https://ncbi.nlm.nih.gov/pubmed/28300658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2017.03.002
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