Efficient and Non-Toxic Biological Response Carrier Delivering TNF-α shRNA for Gene Silencing in a Murine Model of Rheumatoid Arthritis

Small interfering RNA (siRNA) is an effective and specific method for silencing genes. However, an efficient and non-toxic carrier is needed to deliver the siRNA into the target cells. Tumor necrosis factor α (TNF-α) plays a central role in the occurrence and progression of rheumatoid arthritis (RA)...

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Udgivet i:Front Immunol
Main Authors: Song, Jialin, Chen, Yinghui, Jiang, Shichao, Yang, Kejia, Li, Xiaoming, Zhao, Xiaotian, Ouyang, Yuanming, Fan, Cunyi, Yuan, Weien
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990551/
https://ncbi.nlm.nih.gov/pubmed/27594856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00305
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