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Silencing of Cav1.2 gene in neonatal cardiomyocytes by lentiviral delivered shRNA

Cav1.2 (α(1C)) and Cav1.3 (α(1D)) L-type Ca channels are co-expressed in the heart. To date, there are no pharmacological or biophysical tools to separate α(1D) from α(1C) Ca currents (I(Ca-L)) in cardiomyocytes. Here, we established a physiological model to study α(1D) I(Ca-L) in native myocytes us...

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Detalles Bibliográficos
Publicado en:Biochem Biophys Res Commun
Autores principales: Karnabi, Eddy, Qu, Yongxia, Mancarella, Salvatore, Yue, Yuankun, Wadgaonkar, Raj, Boutjdir, Mohamed
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334931/
https://ncbi.nlm.nih.gov/pubmed/19422800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.04.150
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