Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition

Here we show that acute myeloid leukemia (AML) cells require the BRD9 subunit of the SWI/SNF chromatin remodeling complex to sustain MYC transcription, rapid cell proliferation, and a block in differentiation. Based on these observations, we derived small-molecule inhibitors of the BRD9 bromodomain,...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Hohmann, Anja F., Martin, Laetitia J., Minder, Jessica, Roe, Jae-Seok, Shi, Junwei, Steurer, Steffen, Bader, Gerd, McConnell, Darryl, Pearson, Mark, Gerstberger, Thomas, Gottschamel, Teresa, Thompson, Diane, Suzuki, Yutaka, Koegl, Manfred, Vakoc, Christopher R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990482/
https://ncbi.nlm.nih.gov/pubmed/27376689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2115
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