A Tmprss2-CreER(T2) Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon

Fusion between TMPRSS2 and ERG, placing ERG under the control of the TMPRSS2 promoter, is the most frequent genetic alteration in prostate cancer, present in 40–50% of cases. The fusion event is an early, if not initiating, event in prostate cancer, implicating the TMPRSS2-positive prostate epitheli...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gao, Dong, Zhan, Yu, Di, Wei, Moore, Amanda R., Sher, Jessica J., Guan, Youxin, Wang, Shangqian, Zhang, Zeda, Murphy, Devan A., Sawyers, Charles L., Chi, Ping, Chen, Yu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990297/
https://ncbi.nlm.nih.gov/pubmed/27536883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161084
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